|Quick links:||More information about the research groups and programs affiliated with the Epilepsy Research Centre:|
Clinical Genetics Research Group
Paediatric Epilepsy, Autism & Mental Retardation Research
Molecular Genetics Research Group
|Neuroimaging of Epilepsy at Brain Research Institute|
What do we do?
The Epilepsy Genetics group comprises a large clinical epilepsy research team and the Epilepsy Molecular Genetics Laboratory. Together with collaborators at the Women’s & Children’s Hospital and University of South Australia in Adelaide, and at the Walter and Eliza Hall Institute in Parkville, we are international leaders in the genetics of epilepsy.
The Molecular Genetics Laboratory focuses on gene discovery and analysis in both simple Mendelian epilepsies (where one gene is responsible) and complex epilepsies (where multiple genes may play a role). In order to identify and characterise genes involved in epilepsy, the Epilepsy Molecular Genetics Laboratory and its collaborators use current and emerging genetic and molecular techniques, including advanced gene mapping, bioinformatics, database mining and Next Generation sequencing (also known as Massive Parallel Sequencing), as well as PCR and conventional DNA sequencing.
Dr Michael Hildebrand (Laboratory Head, Research Fellow)
Dr Henrik Dahl (Senior Scientist)
John Damiano (Senior Research Assistant)
Elena Aleksoska (Senior Technical Assistant)
PhD and Honours Projects
Project Title: Finding and analysing novel genes for epilepsy
Supervisors: Prof. Sam Berkovic, Dr. Michael Hildebrand and Dr. Henrik Dahl
Description: The Human Genome Project, gene mapping techniques, bioinformatics and Next Generation sequencing are currently revolutionizing gene discovery, leading to the rapid discovery of genes associated with human disease. The Epilepsy Research Centre has over many years studied families with inherited forms of epilepsy and identified several genes associated with this condition. Despite our success, the genetic causes of epilepsy remain unknown in many families. We are currently generating Next Generation sequencing data from 8 families with different types of inherited epilepsy. You will identify and analyse a novel “epilepsy” gene in one or more of these families.
Techniques: This exciting and results-focussed project takes advantage of the large patient material and comprehensive clinical information that we have available. The Epilepsy Molecular Genetics Laboratory and its collaborators use the latest techniques in molecular genetics, including advanced gene mapping, bioinformatics, Next Generation sequencing (also known as Massive Parallel Sequencing), as well as conventional DNA sequencing. You will be involved in the analysis of data from gene mapping and Next Generation sequencing and you will investigate the role and importance of the novel “epilepsy” gene(s) in epilepsy. This will involve database mining, bioinformatics and practical laboratory work (PCR, DNA sequencing etc.).
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Dr Michael Hildebrand
Tel: +613 9035 7059
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Some of Melbourne Molecular Genetics Laboratory's important publications are listed below. More publications from the ERC including other Molecular Genetics papers can be found on the Genetics of Epilepsy page. More publications and details can also be found using the search engine PubMed or on Prof Sam Berkovic, Dr Henrik Dahl, and Dr Michael Hildebrand's University of Melbourne profiles.
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